Gene name:
Maged1 (Nrage) ;
Protein name:
Melanoma-associated antigen D1 ;
Alternative:
Neurotrophin receptor-interacting MAGE homolog ;MAGE-D1 antigen ;Sertoli cell necdin-related gene protein 1 (SNERG-1) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with DLX5, DLX7 and MSX2 and forms homomultimers (By similarity). Interacts with UNC5A.
Function:
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members.
Subcellular Location:
Cytoplasm
Cell membrane
Peripheral membrane protein
Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
Protein Attributes:
50:
MAQKPDGGAG | LRGFQAEASV | EDSALLVQTL | MEAIQISEAP | PTSQATAAAS |
100:
GPNASPQSSQ | PPTANEKADT | EVSAAAARPK | TGFKAQNTTT | KGPNDYSQAR |
150:
NAKEMPKNQP | KVAFKSQNAT | SKGPHAASDF | SHAASTGKSA | AKKSEMAFKG |
200:
QNTTTKAGPS | ATYNFTQSPS | ANEMTNNQPK | TAKAWNDTTK | IPGADAQTQN |
250:
VNQAKMADVG | TSAGISETDG | AAAQTSADGS | QAQNVESRTI | IRGKRTRKIN |
300:
NLNVEENSNG | DQRRASLASG | NWRSAPVPVT | TQNPPGAPPN | VLWQTPLAWQ |
350:
NPSGWQNQTA | RQTPPARQSP | PARQTPSAWQ | NPVAWQNPVI | WPNPVIWQNP |
400:
VIWPNPIVWP | GPIVWPNPMA | WQSTPGWQSP | PSWQAPPSWQ | SPQDWQGPPD |
450:
WQLPPDWSMP | PDWSFPSDWP | FPPDWIPADW | PIPPDWQNLR | PSPNLRSSPN |
500:
SRASQNQGPP | QPRDVALLQE | RANKLVKYLM | LKDYTKVPIK | RSEMLRDIIR |
550:
EYTDVYPEII | ERACFVLEKK | FGIQLKEIDK | EEHLYILIST | PESLAGILGT |
600:
TKDTPKLGLL | LVILGIIFMN | GNRATEAVLW | EALRKMGLRP | GVRHPLLGDL |
650:
RKLLTYEFVK | QKYLDYRRVP | NSNPPEYEFL | WGLRSYHETS | KMKVLRFIAE |
700:
VQKRDPRDWT | AQFMEAADEA | LDALDAAAAE | AEARAEARNR | MGIGDEAVSG |
750:
PWSWDDIEFE | LLTWDEEGDF | GDPWSRIPFT | FWARYHQNAR | SRFPQAFTGP |
775:
IIGPSGTATA | NFAANFGAIG | FFWVE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Rat
Mouse
ELISA Kit for Rat Melanoma-associated antigen D1
ELISA Kit for Rat Melanoma-associated antigen D1
ELISA Kit for Rat Melanoma-associated antigen D1
ELISA Kit for Rat Melanoma-associated antigen D1
CLIA Kit for Rat Melanoma-associated antigen D1
CLIA Kit for Rat Melanoma-associated antigen D1
CLIA Kit for Rat Melanoma-associated antigen D1
CLIA Kit for Rat Melanoma-associated antigen D1
Polyclonal Antibody for Rat Melanoma-associated antigen D1
Polyclonal Antibody for Rat Melanoma-associated antigen D1
Polyclonal Antibody for Rat Melanoma-associated antigen D1
Polyclonal Antibody for Rat Melanoma-associated antigen D1
Monoclonal Antibody for Rat Melanoma-associated antigen D1
Monoclonal Antibody for Rat Melanoma-associated antigen D1
Monoclonal Antibody for Rat Melanoma-associated antigen D1
Monoclonal Antibody for Rat Melanoma-associated antigen D1
Protein for Rat Melanoma-associated antigen D1
Protein for Rat Melanoma-associated antigen D1
Protein for Rat Melanoma-associated antigen D1
Protein for Rat Melanoma-associated antigen D1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION IN APOPTOSIS;INTERACTION WITH NGFR
strain :
Sprague-Dawley .
tissue :
Neural crest .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .
3.
"A novel messenger ribonucleic acid homologous to human MAGE-D is strongly expressed in rat Sertoli cells and weakly in Leydig cells and is regulated by follitropin, lutropin, and prolactin."
Hennuy B.
,
Reiter E.
,
Cornet A.
,
Bruyninx M.
,
Daukandt M.
,
Houssa P.
,
N'Guyen V.-H.
,
Closset J.
,
Hennen G.
Endocrinology141:3821-3831(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 206-775
tissue :
Testis .
4.
"Rattus norvegicus mRNA for SNERG-1 protein, partial CDS."
Zhang C.
,
He F.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 178-775
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UNC5A